Amazon Development Center U.S., Inc.
Posted Nov 2, 2026
Principal Product Designer, AWS Applied AI Solutions
Midtown · Onsite · Senior · $180.4K–$244K
Help moving to NYC
Visa sponsorship likely
Amazon Development Center U.S., Inc. filed 156 NYC H-1Bs, Oct 2025–Jun 2026; this is a technical role. This is historical evidence, not a promise of sponsorship.
Relocation assistance not stated
Relocation assistance is not stated in this posting.
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Pay
Posted$180,400–$244,000 / year
USA, NY, New York - 180,400.00 - 244,000.00 USD annually
H-1B record$179K Company-wide NYC H-1B median offered wage at Amazon Development Center U.S., Inc.: $178,900 (156 filings, Oct 2025–Jun 2026). Not specific to this role.
About the role
Do you want your design work to decide what gets built, rather than describe it afterward?
Amazon builds artificial intelligence systems that scientists and clinicians use to discover new medicines and run clinical trials. Better software here has an unusually direct consequence: therapies reach patients sooner, and scientists spend their time on science.
You will own the end-to-end user experience point of view across that portfolio — from regulated clinical research through computational drug discovery — defining how a scientist works alongside an artificial intelligence teammate rather than operating a tool and proving it with working prototypes that become the specification engineering leverages to build.
Key job responsibilities
Own and defend the user experience point of view across the portfolio, working as a peer to product management, applied science, engineering and architecture rather than downstream of finished requirements.
Define the interaction model for software that acts on a person's behalf — how it shows its evidence, where the person keeps control, what it does when it is wrong, and how work is handed back.
Direct and build high-fidelity working prototypes, and use them as the shared specification that product and engineering develop against.
Mentor and develop other designers across the portfolio through mentoring and shared patterns.
A day in the life
You spend a morning with a computational biologist. She tells you the product output looks plausible and she does not trust it. This is the most consequential thing anyone will say all quarter, and the rest of your week goes into turning it into something the product does differently.
Later that week you present one working flow and three open questions to leadership, arguing that products built separately should reach a customer as one. How that lands decides what gets funded.
Another day you review a prototype of a pattern you specified.
About the team
Life Sciences, within AWS Applied AI Solutions, supports AI products for drug discovery and clinical research. Small team, large surface. Arguments are settled by building and inspecting: prototypes are the primary artifact and the engineering handoff. Regulators shape the products and how research is run, and design has carried much of the product direction, making the role load-bearing, not advisory. UX is horizontal: you succeed when a partner team ships your work. The systems behave like a capable colleague, not a tool, knowing when to act, when to ask, and how to show their work.
10+ years of experience as a practicing product or user experience designer.
Experience designing data-dense enterprise, scientific or technical software.
Experience owning design direction for multiple products or a product portfolio simultaneously.
Experience designing products built on large language models or multi-step automated agents, including how such a system behaves when it fails.
Experience designing for regulated clinical research, drug discovery, or an equivalently regulated scientific domain.
Experience building high-fidelity interactive prototypes.
Experience presenting design work to senior business leadership.
Bachelor's degree, or 10 years of professional design experience in lieu of a degree.
Experience in both regulated clinical research and drug discovery, with the ability to move between those audiences without a translator.
Experience partnering with machine learning or applied science teams on model behavior and evaluation.
Experience designing for reproducible analysis, traceable evidence and visible uncertainty, where a convincing output is not the same as a valid result.
Familiarity with computational protein or antibody design tooling, or with clinical data standards for study data, analysis data and reporting outputs.
Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company’s reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit https://amazon.jobs/content/en/how-we-hire/accommodations for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner.
USA, CA, Sunnyvale - 180,400.00 - 244,000.00 USD annually
USA, NY, New York - 180,400.00 - 244,000.00 USD annually
USA, WA, Seattle - 164,000.00 - 221,800.00 USD annually
Amazon builds artificial intelligence systems that scientists and clinicians use to discover new medicines and run clinical trials. Better software here has an unusually direct consequence: therapies reach patients sooner, and scientists spend their time on science.
You will own the end-to-end user experience point of view across that portfolio — from regulated clinical research through computational drug discovery — defining how a scientist works alongside an artificial intelligence teammate rather than operating a tool and proving it with working prototypes that become the specification engineering leverages to build.
Key job responsibilities
Own and defend the user experience point of view across the portfolio, working as a peer to product management, applied science, engineering and architecture rather than downstream of finished requirements.
Define the interaction model for software that acts on a person's behalf — how it shows its evidence, where the person keeps control, what it does when it is wrong, and how work is handed back.
Direct and build high-fidelity working prototypes, and use them as the shared specification that product and engineering develop against.
Mentor and develop other designers across the portfolio through mentoring and shared patterns.
A day in the life
You spend a morning with a computational biologist. She tells you the product output looks plausible and she does not trust it. This is the most consequential thing anyone will say all quarter, and the rest of your week goes into turning it into something the product does differently.
Later that week you present one working flow and three open questions to leadership, arguing that products built separately should reach a customer as one. How that lands decides what gets funded.
Another day you review a prototype of a pattern you specified.
About the team
Life Sciences, within AWS Applied AI Solutions, supports AI products for drug discovery and clinical research. Small team, large surface. Arguments are settled by building and inspecting: prototypes are the primary artifact and the engineering handoff. Regulators shape the products and how research is run, and design has carried much of the product direction, making the role load-bearing, not advisory. UX is horizontal: you succeed when a partner team ships your work. The systems behave like a capable colleague, not a tool, knowing when to act, when to ask, and how to show their work.
10+ years of experience as a practicing product or user experience designer.
Experience designing data-dense enterprise, scientific or technical software.
Experience owning design direction for multiple products or a product portfolio simultaneously.
Experience designing products built on large language models or multi-step automated agents, including how such a system behaves when it fails.
Experience designing for regulated clinical research, drug discovery, or an equivalently regulated scientific domain.
Experience building high-fidelity interactive prototypes.
Experience presenting design work to senior business leadership.
Bachelor's degree, or 10 years of professional design experience in lieu of a degree.
Experience in both regulated clinical research and drug discovery, with the ability to move between those audiences without a translator.
Experience partnering with machine learning or applied science teams on model behavior and evaluation.
Experience designing for reproducible analysis, traceable evidence and visible uncertainty, where a convincing output is not the same as a valid result.
Familiarity with computational protein or antibody design tooling, or with clinical data standards for study data, analysis data and reporting outputs.
Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Los Angeles County applicants: Job duties for this position include: work safely and cooperatively with other employees, supervisors, and staff; adhere to standards of excellence despite stressful conditions; communicate effectively and respectfully with employees, supervisors, and staff to ensure exceptional customer service; and follow all federal, state, and local laws and Company policies. Criminal history may have a direct, adverse, and negative relationship with some of the material job duties of this position. These include the duties and responsibilities listed above, as well as the abilities to adhere to company policies, exercise sound judgment, effectively manage stress and work safely and respectfully with others, exhibit trustworthiness and professionalism, and safeguard business operations and the Company’s reputation. Pursuant to the Los Angeles County Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.
Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit https://amazon.jobs/content/en/how-we-hire/accommodations for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner.
The base salary range for this position is listed below. Your Amazon package will include sign-on payments and restricted stock units (RSUs). Final compensation will be determined based on factors including experience, qualifications, and location. Amazon also offers comprehensive benefits including health insurance (medical, dental, vision, prescription, Basic Life & AD&D insurance and option for Supplemental life plans, EAP, Mental Health Support, Medical Advice Line, Flexible Spending Accounts, Adoption and Surrogacy Reimbursement coverage), 401(k) matching, paid time off, and parental leave. Learn more about our benefits at https://amazon.jobs/en/benefits.
USA, CA, Sunnyvale - 180,400.00 - 244,000.00 USD annually
USA, NY, New York - 180,400.00 - 244,000.00 USD annually
USA, WA, Seattle - 164,000.00 - 221,800.00 USD annually